MEDIPOST America clears Phase 1/2 IND for the U.S. clinical trial on stem cell drug for lung

MEDIPOST America Inc. today announced the US FDA approval of Phase 1/2 clinical trial for PNEUMOSTEM.

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MEDIPOST America clears Phase 1/2 IND for the U.S. clinical trial on stem cell drug for lung

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James Collins to receive the 2015 HFSP Nakasone Award

PUBLIC RELEASE DATE:

8-Sep-2014

Contact: Guntram Bauer gbauer@hfsp.org 33-388-215-124 Human Frontier Science Program

The Human Frontier Science Program Organization (HFSPO) has announced that the 2015 HFSP Nakasone Award has been conferred upon James Collins of Boston University and Harvard’s Wyss Institute for his innovative work on synthetic gene networks and programmable cells which launched the exciting field of synthetic biology.

The HFSP Nakasone Award was established to honour scientists who have made key breakthroughs in fields at the forefront of the life sciences. It recognizes the vision of former Prime Minister Nakasone of Japan in the creation of the Human Frontier Science Program. James Collins will present the HFSP Nakasone Lecture at the 15th annual meeting of HFSP awardees to be held in La Jolla, California, in July 2015.

James Collins was one of the first to show that one can engineer biological circuits out of proteins, genes and other bits of DNA. He designed and constructed a genetic toggle switch – a bistable gene circuit with broad implications for biomedicine and biotechnology. This work represents a landmark in the beginnings of synthetic biology. He showed that synthetic gene networks can be used as regulatory modules and interfaced with the cell’s genetic circuitry to create programmable cells for biomedical and biotech applications. Along these lines, Collins has developed whole-cell biosensors to detect various stimuli (chemicals, pathogens, heavy metals, explosives), as well as synthetic probiotics to detect and treat infections (e.g., cholera). Collins has also designed and constructed RNA switches, genetic counters, programmable microbial kill switches, synthetic bacteriophages to combat bacterial infections, genetic switchboards for metabolic engineering, synthetic mRNA for stem cell reprogramming, and tunable mammalian genetic switches.

Collins’ innovative work in synthetic biology is impacting the biosciences and the biotech industry in providing one of the key enabling technologies of the 21st century. His engineered gene circuits and synthetic biology technology have been utilized by multiple companies in diverse fields ranging from agriculture to drug discovery. His work has inspired scientists around the world and enabled multiple biomedical applications, including in vivo bio-sensing, antibiotic potentiation, biofilm eradication, drug target identification and validation, microbiome reengineering, and efficient stem cell reprogramming and differentiation. Collins’ mammalian switch technology is being used by research groups worldwide and his programmable microbial kill switch was highlighted by President Obama’s Bioethics Commission as a much-needed safeguard for real-world applications of synthetic biology.

The work of James Collins is advancing, if not defining, the emerging discipline of synthetic biology, and his path-blazing research on synthetic gene networks and programmable cells is transforming the life sciences and expanding our ability to study and harness complex mechanisms of living organisms.

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The HFSP Nakasone Award was established in 2010. Previous recipients have been Karl Deisseroth (2010), Michael Elowitz (2011), Gina Turrigiano (2012), Stephen Quake (2013), and Uri Alon (2014).

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Should scientists handle retractions differently?

PUBLIC RELEASE DATE:

4-Sep-2014

Contact: Abby Abazorius abbya@mit.edu 617-253-2709 Massachusetts Institute of Technology

It is one of the highest-profile cases of scientific fraud in memory: In 2005, South Korean researcher Woo-Suk Hwang and colleagues made international news by claiming that they had produced embryonic stem cells from a cloned human embryo using nuclear transfer. But within a year, the work had been debunked, soon followed by findings of fraud. South Korea put a moratorium on stem-cell research funding. Some scientists abandoned or reduced their work in the field.

But the case is not so simple: By 2007, other stem-cell researchers had found that the debunked research contained a few solid findings amid the false claims. While prior stem-cell findings remained intact, it took time to rebuild support for the field.

Now a study by MIT scholars quantifies the fallout for scientists whose fields suffer high-profile retractions, with a twist: Even valid older research, when cited in a retracted study, loses credibility especially if the retracted paper involves malfeasance. The fallout from a retraction does not land solely on the scientists who are at fault, but on people in the field more broadly.

As the new paper contends, “scientific misconduct and mistakes, as signaled to the scientific community through retractions, cause a relative decline in the vitality of neighboring intellectual fields.” This spillover effect, which includes a 6 percent decline in citations relative to similar, unaffected papers, suggests that scientists would benefit by trying to describe the nature of each retraction in more detail.

“A well-functioning, transparent retraction process is actually part and parcel of the scientific system,” says Pierre Azoulay, an economist at the MIT Sloan School of Management, and a co-author of the new study. “We need a system where journals help the readers spell out the reasons for the retractions, and help the scientific community parse the implications for the forward movement of science.”

Identifying the “stigma story”

The paper, “Retractions,” is published in the Review of Economics and Statistics, a peer-reviewed economics journal. The authors are Azoulay, the Sloan Distinguished Associate Professor of Management; Fiona Murray, the Alvin J. Siteman Professor of Entrepreneurship, associate dean for innovation at MIT Sloan, and co-director of MIT’s Innovation Initiative; Joshua Krieger, a doctoral student at MIT Sloan; and Jeffrey Furman, an economist at Boston University.

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Should scientists handle retractions differently?

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Morning Briefing

Commentary: Considering three factors at play in Ferguson by Mary Ann McGivern

Chicago — Archdiocese clears pastor of abuse allegation

Cincinnati — Catholic school principals told not to raise money for ALS association , which funds at least one study using embryonic stem cells.

Centers for Disease Control and Prevention: Teenage pregnancy is down in the United States. This reduction could save taxpayers money, based on a new study.

Greensburg, Pa. — A federal judge granted a permanent injunction to the Catholic diocese of Greensburg that halts the enforcement of the Affordable Care Act.

Help keep NCR going! We rely on donations to bring you the latest news. Donate today.

Hobby Lobby fallout: The Illinois proposal aims to coax more health care providers into expanding family planning services by increasing their reimbursement rates starting Oct. 1. Officials are weighing whether the state has the legal authority to require health care providers that do not provide contraceptive services to refer interested patients to institutions that do offer the information.

Commentary: Ireland — Abortion law offers escape to rich and a dead end to poor. nobody who can actually bear children in Ireland today — nobody under the age of 49 — has had any real say over our draconian abortion regime.

Stack and Rose are millennial activists. For all their political differences, Stack and Rose have quite a bit in common. Both were raised in large, religious families. Both learned the values of social justice from nuns. They both turn 26 this summer. Both consider themselves feminists and speak in that patois, using words like empowerment and choice.The Abortion War’s Special Ops

Oklahoma City — Catholic bishop sues over planned black mass to halt the use of what he said were stolen communion wafers

Excerpt from:
Morning Briefing

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The regeneration of stem cell research in South Korea …

TOKYO — Nearly a decade after a star scientist’s faked papers set back South Korean research on regenerative medicine, industry, government and academia are making a renewed push. Scientists in the country are progressing toward practical use of versatile cells, particularly embryonic stem (ES) cells from fertilized eggs.

Hwang Woo-suk, then a professor at Seoul National University, rose to prominence around the turn of the century as a result of his work cloning animals and, later, developing stem cells derived from cloned human embryos. But in 2005, a scandal erupted over fabrications in his papers on the stem cell technology.

Today, South Korea’s scientific community appears to be leaving the controversy behind as it pursues a range of ambitious projects.

The CHA Bio Complex on the outskirts of Seoul

The CHA Bio Complex on the outskirts of Seoul

The renaissance is evident in Pangyo Techno Valley, a high-tech zone on the outskirts of Seoul. An enormous building with curved walls resembling the double-helix structure of DNA was completed there in late May. It is home to the CHA Bio Complex, a place for collaboration between universities, research labs and biotechnology companies affiliated with major medical group CHA Health Systems.

More than 1,000 researchers toil in the building, which has some 60,000 sq. meters of floor space. They are mainly focusing on ES cells and stem cells cultivated into specific tissues. They have established South Korea’s largest ES cell bank and are collecting 50 lines — groups of stem cells that can be propagated on and on. These lines are produced from fertilized human eggs and registered with government institutions.

The research at the CHA Bio Complex is expected to lead to clinical trials at a general hospital in the group, located about five minutes away by car. A treatment for age-related macular degeneration, an incurable eye disease, has already reached the trial stage. Retinal cells created from ES cells were transplanted into four patients, and after six months to a year, no serious side effects were observed.

The South Korean scientists are also looking into induced pluripotent stem (iPS) cells. They hope to work with Japanese universities and hospitals, which have zeroed in on this technology. Still, ES studies remain the focus in Seoul, since they are further along.

Cell clones

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The regeneration of stem cell research in South Korea …

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Trying out a stem cell facial

TO SOME people, the term stem cell may seem kind of taboo. I personally would not want something from animals injected into my system. But Im okay with non-invasive treatments, so I was interested to try out a plant-based stem cell facial.

After cleansing and toning, cotton pads moistened with a clear solution were laid on my eyelids to protect them from a three-minute steaming session. This was followed by a special tool called a scrubber that kind of looks like a computer mouse, but helps to remove dead skin cells and unblock pores without using the rather painful pricking tool.

Next, a rejuvenating gel was applied, followed by the plant-derived stem cell formula. A unique cooling machine was used to massage it into the skin for 10 minutes. Using this machine for cold electrophoresis helps the skin absorb serums and vitamins, without having to use injections. This was great for someone like me, who is wary of invasive treatments. The cooling machine feels like having an ice-cold metal ball massaged on the face; very invigorating, indeed.

Just when I thought my skin already got a lot of pampering, the stem cell was followed by a face mask full of natural vitamins. While it penetrated into my skin, I was given an arm and foot massage, which was nice for further relaxation.

With my combination skin, I looked pretty greasy right afterwards. When I woke up the next day, I didnt see a visible difference in my skin, but it was very smooth and supple to the touch. You may not see instant results with a treatment like this, but its a good treatment to maintain radiance, softness and hydration from beneath the surface of the skin.

This type of facial is not recommended for those with oily or acne-prone skin because the added oiliness may exacerbate problems, but it is ideal for those with dry or mature skin, as it is deeply nourishing and moisturizing. After the first treatment or over time, depending on the condition of your skin, stem cell diminishes fine lines, prevents wrinkles, and promotes cell renewal (a process that slows with age) to give that glowing look that signifies healthy, youthful skin.

I tried out the stem cell facial at Lohas skin and slimming center on Paseo Saturnino, Banilad. Its a more upscale experience here with your own room, as opposed to being in one large room with dividers, in case privacy is an issue for you. All of their machines and products are brought in from Korea and their staff, like my therapist Jennylyn, are highly knowledgeable and know just how much pressure to apply during the treatment. The service, facilities and products used add up to a luxurious treatment session that makes one feel very pampered.

Published in the Sun.Star Cebu newspaper on August 15, 2014.

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STEMS Regenerative Medicine – stem cell regenerative medicine

Language Translation: http://languagetranslator.herokuapp.com/

Affiliated Hospitals in China http://en.tedaich.com/ http://www.puhuachina.com/

Awards: 2011 Case Report of the Year Award by BioMedCentral (BMC) http://www.biomedcentral.com/researchawards/award2011

Publications by Jae W. Pak, MD: 1. JMCR. Regeneration of Bones in Hip Osteonecrosis and Cartilage in Knee Osteoarthritis with adipose tissue-derived stems cells in human. Journal of Medical Case Reports July 2011. http://www.jmedicalcasereports.com/content/5/1/296

2. Pain Physician. Autologous Adipose Tissue-Derived Stem Cells Induce Persistent Bone-Like Tissue in Osteonecrotic Femoral Heads.Pain Physician Jan/Feb 2012, vol 15, issue 1, Page 75-85 http://www.painphysicianjournal.com/crrent_issue_vw.php?journal=65&code=1574&issue=past_issue

3. PLOS One. A novel biological approach to treat chondromalacia patellae.PLOS ONE May 2013.PLoS ONE 8(5): e64569. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0064569

4. BMC Musculoskeletal disorders 2013,J. Pak et al. Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints.BMC Musculoskeletal Disorders 2013, 14:337 http://www.biomedcentral.com/1471-2474/14/337

5. BioMed Research International Review Article”Regenerative repair of damaged meniscus with autologous adipose-tissue-derived stem cells,” BioMed Research International, vol. 2014, Article ID 436029, 10 pages, 2014. http://www.hindawi.com/journals/bmri/2014/436029/

6.BioMed Research InternationalClinical applications of platelet-rich plasma in patellar tendinopathy.BioMed Research International, vol. 2014, Article ID 436029, 10 pages, 2014. http://www.hindawi.com/journals/bmri/2014/249498/

However, adipose (fat) tissue-derived repair stem cells (aka ADSCs)can becollected by a liposuction of the patient and injected into the lesion along with PRP.

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STEMS Regenerative Medicine – stem cell regenerative medicine

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My ring bling thing

As cell phones become ever more essential (Are they really mobile if theyre permanently attached to us?), they become a kind of archeological artifact, something that speaks about us as much as to us.

Researchers at Penn State conducted a study looking at how persons of different cultures chose and customized their phones protective cases. People from Eastern cultures, such as Japan and South Korea, tended to be more motivated to change the look and sound of their mobile phones.

People who live in collectivist cultures are often more other-directed, said study author S. Shyam Sundar. They want to know how others might look at them and also look at others as a way of influencing their own behaviors.

Thus, Eastern cultures were more likely to spruce up cases with charms, stickers and noticeably alter functions like ringtones and screen wallpapers all to more clearly fit within a social set. Conversely, the researchers said Americans appeared to worry less about how others perceived them and, perhaps contrarily, customized less.

Still, overall cell phone users are increasingly blinging out their phones, which they view as not merely a communications tool, but as a way to communicate to others who they are.

Medical history

This week in 1997, it was announced the first human stem cells had been cultured in a laboratory by researchers at Johns Hopkins University. The cells were derived from embryonic tissue.

Phobia of the week

Chaetophobia fear of hair

Body of knowledge

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My ring bling thing

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Stem Cell Therapy in South Korea | The Help of Stem Cells

Originally posted by PlacidWay here:

Alzheimers disease treatment with stem cells is an alternative treatment that focuses on re-establishing neuronal connections lost. Because Alzheimers is a neurodegenerative condition that affects the brain, scientists are constantly researching ways to tackle the diseases symptoms, while, on the other hand, the specific cause of Alzheimer and the complete cure are still under research.

Alzheimers is actually a form of dementia, which shows progressive neurological degeneration. Spotting the signs in the early stage is crucial, as the chances for successful treatment are lower as the disease progresses. See here the signs of Alzheimers disease.

Stem cells are cells responsible with regenerating, being part of the bodys own repair mechanism. As research has shown, several types of regenerative cells treatments have been effective in treating Alzheimers disease:

The medical centers that have been successfully processing stem cells for use in treating the symptoms of Alzheimers disease worldwide:

Swiss Medica Starting from $17,000

Stem Cell Therapy in Switzerland & Serbia

Stem Cell Therapy Vienna Starting from $21,000

Stem Cell Technologies in Austria

Integra Medical Center Starting from $14,000

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What increases the neuronal plasticity of endogenous NSCs after focal cerebral ischemia?

PUBLIC RELEASE DATE:

15-Jul-2014

Contact: Meng Zhao eic@nrren.org 86-138-049-98773 Neural Regeneration Research

Stem cells can substitute the lost cells after central nervous system injury, decrease nervous tissue damage and promote neurofunctional recovery. Many brain injury models, including middle cerebral artery occlusion and traumatic brain injury models, have confirmed that neural stem cells (NSCs) can migrate from subventricular zone to injured cerebral cortex. But the mechanism underlying activation of endogenous NSCs in the ischemic brain remains unclear. Dr. Hyung-Seok Kim, Chonnam National University Medical School, Korea and his team revealed that NSCs were activated sequentially after focal cerebral ischemia and validated that early expressions of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor increase the neuronal plasticity of activated endogenous NSCs after focal cerebral ischemia. Moreover, neural precursor cells after large-scale cortical injury could be recruited from the cortex nearby infarct core and subventricular zone. Related results were published in Neural Regeneration Research (Vol. 9, No. 9, 2014).

Article: ” Early expressions of hypoxia-inducible factor 1alpha and vascular endothelial growth factor increase the neuronal plasticity of activated endogenous neural stem cells after focal cerebral ischemia” by Seung Song1, Jong-Tae Park1, Joo Young Na1, Man-Seok Park2, Jeong-Kil Lee3, Min-Cheol Lee4, Hyung-Seok Kim1, 4 (1 Department of Forensic Medicine, Chonnam National University Medical School, Gwangju, Korea; 2 Department of Neurology, Chonnam National University Medical School, Gwangju, Korea; 3 Department of Neurosurgery, Chonnam National University Medical School, Gwangju, Korea; 4 Department of Pathology, Chonnam National University Medical School, Gwangju, Korea)

Song S, Park JT, Na JY, Park MS, Lee JK, Lee MC, Kim HS. Early expressions of hypoxia-inducible factor 1alpha and vascular endothelial growth factor increase the neuronal plasticity of activated endogenous neural stem cells after focal cerebral ischemia. Neural Regen Res. 2014;9(9):912-918.

Contact: Meng Zhao eic@nrren.org 86-138-049-98773 Neural Regeneration Research http://www.nrronline.org/

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